How to use SciPy Least Squares to minimize multiple functions at once

SciPy comes with a least squares Levenberg-Marquardt implementation. This allows you to minimize functions. By defining your function as the difference between some measurements and your model function, you can fit a model to those measurements.

Sometimes your model contains multiple functions. You can also minimize for all functions using this approach:

• Define your functions that you like to minimize A(p0), B(P1), ...
  their cumulative paramaters will be a tuple (p0, p1, ...).
• Define your function to be minimized as f(x0), where x0 is expanded to the parameter tuple.
• The function f returns a vector of differences between discrete measured sample and the individual functions A, B etc.
• Let SciPy minimize this function, starting with a reasonably selected initial parameter vector.

This is an example implementation:

import math
import scipy.optimize

measured = { 
    1: [ 0, 0.02735, 0.47265 ],
    6: [ 0.0041, 0.09335, 0.40255 ],
    10: [ 0.0133, 0.14555, 0.34115 ],
    20: [ 0.0361, 0.205, 0.2589 ],
    30: [ 0.06345, 0.23425, 0.20225 ],
    60: [ 0.132, 0.25395, 0.114 ],
    90: [ 0.2046, 0.23445, 0.06095 ],
    120: [ 0.2429, 0.20815, 0.04895 ],
    180: [ 0.31755, 0.1618, 0.02065 ],
    240: [ 0.3648, 0.121, 0.0142 ],
    315: [ 0.3992, 0.0989, 0.00195 ]
}

def A( x, a, k ):
    return a * math.exp( -x * k )

def B( x, a, k, l ):
    return k * a / ( l - k ) * ( math.exp( -k * x ) - math.exp( -l * x ) )

def C( x, a, k, l ):
    return a * ( 1 - l / ( l - k ) * math.exp( -x * k ) + k / ( l - k ) * math.exp( -x * l ) )

def f( x0 ):
    a, k, l = x0
    error = []
    for x in measured:
        error += [ C( x, a, k, l ) - measured[ x ][ 0 ],
                   B( x, a, k, l ) - measured[ x ][ 1 ],
                   A( x, a, k ) - measured[ x ][ 2 ]
               ]
    return error

def main():
    x0 = ( 0.46, 0.01, 0.001 ) # initial parameters for a, k and l
    x, cov, infodict, mesg, ier = scipy.optimize.leastsq( f, x0, full_output = True, epsfcn = 1.0e-2 )
    print x

if __name__ == "__main__":
    main()

SciPy returns a lot more information, not only the final parameters. See their documentation for details. You also may want to tweak epsfcn for a better fit. This depends on your functions shape and properties.